托伐普坦治疗慢性心力衰竭的疗效及安全性

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Abstract Objective To explore the curative effect and safety of tolvaptan on patients of chronic heart failure(CHF).Methods Sixty patients with chronic heart failure were randomly divided into the control group and observation group(30 cases in each group).The control group was given traditional anti-CHF therapy while the observation group was given traditional anti-CHF therapy plus tolvaptan. The changes of 24 h urine volume、blood sodium、blood potassium、blood urea nitrogen、 creatinine、uric acid、B-type natriuretic peptid(BNP)and left ventricular ejection fraction(LVEF)were detected before treatment and 7 days after treatment. The curative effect of tolvaptan was assessed.Results After 7 days of treatment, 24 h urine volume and blood sodium significantly improved,while the level of BNP decreased in the two groups(P<0.05). Compared with the control group,the level of blood urea nitrogen and creatinine decreased and LVEF increased in the observation group(P<0.05). but the level of uric acid and blood potassium did not significantly change. The total effective rate of the observation group(90.0%)was higher than that of the control group(63.3%)(P<0.05).The difference in the incidence of adverse reactions was of no statistical significance between the two groups(P>0.05).Conclusions Tolvaptan can effectively improve the clinical symptom,correct low sodium blood sickness,improve the cardiac and renal function, cause no electrolyte disturbances or fewer adverse reactions in patients with chronic heart failure.

Key words： tolvaptan chronic heart failure blood sodium blood urea nitrogen、creatinine BNP LVEF

Received: 04 December 2017

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	PENG Yanling
	HUANG Jie
	MA Dongxing.

Cite this article:

PENG Yanling,HUANG Jie,MA Dongxing.. Effect of tolvaptan on patients with chronic heart failure[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(6): 578-581.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I6/578

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