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武警医学  2024, Vol. 35 Issue (9): 745-748    DOI:
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2型糖尿病患者血胆红素与糖脂代谢及甲状腺功能的相关性
杨涛1, 刘冀琴2, 张华2, 靳颖2
1.750001 银川,武警宁夏总队医院检验与病理科;
2.300162 天津,武警特色医学中心检验科
Correlation of bilirubin with glucose and lipid metabolism and thyroid function in type 2 diabetic patients
YANG Tao1, LIU Jiqin2, ZHANG Hua2, JIN Ying2
1. Department of Clinical Experiment, Ningxia Autonomous Regional Corps Hospital of Chinese People’s Armed Police Force, Yinchuan 750002, China;
2. Department of Clinical Experiment, Characteristics Medical Center of Chinese People’s Armed Police Force, Tianjin 300162, China

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摘要 

目的 探讨2型糖尿病(T2DM)血胆红素与糖脂代谢及甲状腺功能的相关性。方法 回顾性分析2022-01至2023-08武警特色医学中心收治的T2DM患者170例(T2DM组)的临床资料,另选取89例健康体检者为对照组(NC组)。T2DM 组根据 HbA1c 控制情况分为血糖控制良好亚组(H1)、血糖控制欠佳亚组(H2)及血糖控制差亚组(H3)。根据血脂水平分为血脂正常亚组(L1)及血脂异常亚组(L2)。比较各组间生化指标差异,并分析各指标与胆红素的相关性。结果 T2DM组血清总胆红素(TBil)、直接胆红素(DBil)、促甲状腺激素(TSH)、游离T3(FT3)显著降低(P<0.05)。H3亚组FT3低于H1亚组(P<0.05),H2和H3亚组游离T4(FT4)高于H1亚组(P<0.05)。L2亚组TBil、DBil显著低于L1亚组(P<0.05)。Pearson相关分析显示,TBil、DBil均与TSH呈负相关(P<0.05),DBil还与TC、TG、LDL-C呈负相关(P<0.05)。多元逐步回归分析显示,TSH、TC、LDL-C、HbA1c分别是TBil和DBil的影响因素。结论 T2DM患者血胆红素与糖脂代谢及甲状腺功能指标显著相关。

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杨涛
刘冀琴
张华
靳颖
关键词 糖尿病,2 型胆红素糖脂代谢甲状腺功能    
Abstract

Objective To investigate the correlation between bilirubin and glucose and lipid metabolism and thyroid function in patients with type 2 diabetes mellitus (T2DM). Methods A total of 170 patients with type 2 diabetes mellitus admitted to Characteristics Medical Center of Chinese People's Armed Police Force and another 89 healthy people were selected. Based on HbA1c control, T2DM patients were divided into subgroups with good blood glucose control (H1), poor glucose control (H2) and very poor glucose control (H3). According to the level of blood lipid, T2DM patients were divided into subgroups with normal blood lipids (L1) and high blood lipids (L2). The difference of biochemical indices among all groups was compared, and the correlation between each index and bilirubin was analyzed. Results Compared with NC group, TBil, DBil, TSH and FT3 decreased in T2DM group (P<0.05). The level of FT3 in H3 subgroup was lower than that in H1 subgroup (P<0.05), and the level of FT4 in H2 and H3 subgroup were higher than that in H1 subgroup (P<0.05). The TBil and DBil of L2 subgroup were significantly lower than those of L1 subgroup (P<0.05). TSH was negatively correlated with TBil and DBil (P<0.05), and DBil was also negatively correlated with TC, TG and LDL-C (P<0.05). Multiple stepwise regression analysis showed that TSH, TC, LDL-C and HbA1c were influencing factors for TBil and DBil. Conclusions Bilirubin is closely related with glucose and lipid metabolism and thyroid function in T2DM patients.

Key wordsdiabetes mellitus,type 2    bilirubin    glucose and lipid metabolism    thyroid function   
收稿日期: 2024-01-26     
ZTFLH: R587.1  
通讯作者: 靳 颖,E-mail:jinying9032@hotmail.com   
作者简介: 杨 涛,本科学历,主管技师。
引用本文:   
杨涛, 刘冀琴, 张华, 靳颖. 2型糖尿病患者血胆红素与糖脂代谢及甲状腺功能的相关性[J]. 武警医学, 2024, 35(9): 745-748. YANG Tao, LIU Jiqin, ZHANG Hua, JIN Ying. Correlation of bilirubin with glucose and lipid metabolism and thyroid function in type 2 diabetic patients. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(9): 745-748.
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