Effect of non-invasive positive pressure ventilation on arrhythmia and heart function in patients with coronary heart disease complicated with obstructive sleep apnea hypopnea syndrome
Abstract： Objective To investigate the efficacy of non-invasive positive pressure ventilation in patients with coronary heart disease complicated with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Eighty-six patients with coronary heart disease (CHD) complicated with obstructive sleep apnea hypopnea syndrome (OSAHS) admitted to our hospital between June 2014 and June 2015 were randomly divided into the control group (standard treatment,n=43) and the observation group (standard treatment plus non-invasive positive pressure ventilation,n=43) to observe the impact of clinical treatment on arrhythmia.Results After treatment, the observation group saw remarkable changes in the following indicators: significant increase of Low SaO2 (from 89.5±3.1 to 94.5±4.5), apparent decrease of both AHI (from 9.8±3.2 to 1.6±0.4) and TST SaO2<90% (from 58.8±6.3 to 18.5±6.5), lowered left ventricular end systolic internal diameter (from 37.5±2.3 to 35.0±1.5), lowered end diastolic internal diameter (from 49.2±3.6 to 45.1±3.2), increased left ventricular ejection fractions (LVEF) (from 0.52±0.05 to 0.59±0.05), lowered maximum nighttime heart rate (from 105.6±12.3 to 87.5±9.7) and higher minimum nighttime heart rate (from 47.5±8.3 to 62.5±6.3).An apparent decrease was also found in supraventricular arrhythmias (from 915.5±97.4 to 213.2±50.3) and ventricular arrhythmias (from 483.2±50.4 to 107.2±30.9). The above indicators of blood gas, echocardiography and dynamic electrocardiograms were all remarkably improved in the observation group compared with the control group (P＜0.05).Conclusions The use of noninvasive mechanical ventilation in the treatment of coronary heart disease complicated with OSAHS can effectively improve patients’ blood gas indicators, reduce arrhythmia, correct nocturnal hypoxemia and improve heart function, so this approach is worthy of wide clinical application.
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2018, Vol. 29 
