Therapeutic effects of enteral nutrition combined with probiotics against moderate to severe ulcerative colitis
ZHUANG Wei1 DONG Yuru2
1. Department of Gastroenterology,China Coast Guard Hospital of Chinese People's Armed Police Force,Jiaxing 314000,China; 2. Department of Radiology,the Third Medical Center of PLA General Hospital,Beijing 100039,China
Abstract：Objective To investigate the therapeutic effects of enteral nutrition combined with probiotics against moderate to severe ulcerative colitis(UC).Methods A total of 85 patients with moderate to severe UC admitted to our hospital between January 2015 and December 2019 were randomly divided into the control group (42 cases) and observation group (43 cases).The control group was treated with probiotics alone while the observation group was treated with enteral nutrition combined with probiotics.The clinical efficacy of the two groups was compared based on the levels of body mass index (BMI),albumin (ALB),hemoglobin (HGB),total protein (TP) and other nutritional status indicators as well as levels of serum endomycin (ET),interleukin 4 (IL-4) and peripheral blood CD4+CD5+.Results The total effective rate of treatment was 93.02% in the observation group,significantly higher than 76.19% in the control group,so the difference was statistically significant (P<0.05).Levels of BMI,ALB,HGB and TP were higher in both groups after treatment,especially in the observation group,with statistically significant difference (P<0.05).The serum ET level in the observation group was lower than of the control group,but the serum levels of IL-4 and CD4+CD5+ in peripheral blood were higher,with statistically significant difference (P<0.05).Conclusions Enteral nutrition combined with probiotics is effective in the treatment of moderate to severe UC,which can improve the nutritional status of patients,regulate their immune function,and is worthy of clinical application.
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2020, Vol. 31 
