Abstract: in this paper, on the basis of new economic geography theory, put forward the theory framework of science and technology service industry cluster, to explore the causes and development trend of China's science and technology service, and with the data of 222 ground level above cities are the empirical analysis. Related model is established on the basis of domestic and foreign literature, to the empirical knowledge spillover, informationization, the urban scale, the government policy is beneficial to science and technology service, show that the difference of regional development, based on the heterogeneity characteristic, the east and parts of the Midwest group has a different path. On this basis, this paper based on the development of Chinese city differentiation and technology service industry heterogeneity countermeasures and Suggestions are put forward.