Abstract: Reverse innovation plays an important role in the innovation catch-up of latecomer enterprise. Based on the Emerging market countries to multinational companies cases, analyzing the opportunity and the support capability of reverse innovation. Research findings, the opportunity of reverse innovation presents diversity, niche market and mainstream market are all the standpoint of reverse innovation, “niche” opportunities including product niche and process niche. Different opportunities of reverse innovation, the required capability to support the reverse innovation is different. Based on process niche, the critical supporting ability includes absorptive capacity, technical search ability and marketing ability. Based on product niche, cooperative learning ability, cognitive ability of the marketing character and ability of technical adaptive improvement are the critical abilities. Based on mainstream market, the key supporting ability includes independent innovation ability and the ability of use external resources through multiple channels.