Abstract: The core of industrial technology innovation alliance is the focal firm. Whether the focal firm can choose appropriate cooperation partners and form cooperative symbiosis is the key to efficient operation of industrial technology innovation alliance, and the determinants of industrial technology innovation alliance success and the overall system function. This study illustrates the connotation of the focus firm and its role in the industrial technology innovation alliance, allocates the benefits of cooperation by using the Shapley value method according to the partners’ contribution to the alliance, and forms a comprehensive benefit transfer mechanism. Comprehensive benefit transfer mechanism ensures that all cooperative symbiosis body can obtain reasonable profits from symbiotic cooperation, realizes the mutualism of the cooperative symbiosis body. It is the basic power of cooperative symbiosis body participate cooperation and promote the development of industrial technology innovation alliance, and also the important motivation of focal firm symbiotic cooperation partner selection.