Abstract: This paper first constructs a theoretical framework that green R&D investment influences "Made in China" upgrade from the perspective of the global value chains specialization.On the basis of this, the author builds the index system of "China Manufacturing" upgrade from the three aspects of the height of industry, the carbon productivity of export sector and the technological content of export products, and then use 30 provincial sample data to test the effect of green R&D investment on the "Made in China" upgrade. The result of empirical test shows that: (1) "China-made" upgrade level in the year 2002 to 2015 shows "V" type trend，descending first and then slowly rising, and descends in the order of the eastern region, the central region and the western region . (2) On average, there is a U-type relationship between green R&D investment and the level of "Made in China" upgrade, which means the initial weaker intensity of green R&D investment weakens the level of upgrading of "Made in China", however, with the increase of intensity of green R&D investment, the level of upgrading of "Made in China" increases.There are some differences of the impact of green R&D Investment on the level of "Made in China" Upgrading in different economic zones, different human capital regions, and different intellectual property protection regions. (3)The embedding degree of global value chain and capital intensity have a significant promotion effect on the "Made in China" upgrade, and the effect of marketization on the "Made in China" upgrade is not obvious.