Abstract: The development of Science of Science in China is synchronous with the opening up reform and the spring of science from 1978. At the beginning of Tsien Hsueshen's advocacy of building Science of Science in China, it has experienced the rising, disciplinization and institutionalization during the first ten years; then the research has extended to the field of technology innovation during the second ten years; then, it has experienced the rejuvenation with many emerging subjects, especially on the knowledge-based economy during the third ten years; In the last ten years, science has returned to its own method research, and highlight the scientometrics and its combination with information visualization. The 40 years story reveals that the Science of Science in China follows the spiral development model from top to bottom, from practice to theory, from theory to method, and from method to practice again. With the increasing strategic status of science and technology and the increasing development of information technology, the Science of Science in China is beginning a new round of rising period, another spring of the Science of Science.