Abstract: Industrial digitization is the main driving force for the high-quality development of China's digital economy. Based on technology-organization-environment (TOE) framework, this paper provides the integrated analysis framework of industry digitalization. Also, this paper employs QCA methods to explore the development of underdeveloped regions and developed regions in China on industry digitalization. Results show that high level of regional industry digitalization has three driven paths in underdeveloped regions, and high level of regional industry digitalization has two driven paths in developed regions. And the two types of regions have the common driven paths, but also have different configurational driven paths to high development of industry digitalization in China. In addition, the driven path about high development of industry digitalization has the different essential core conditions in the two regions, and the substitution relationship among technology, organization and environment is also different. The conclusions of this study are helpful to understand the nature of complex interaction among multiple factors behind the development of local digital economy. And they bring beneficial practice enlightenments and useful policy advices for industrial digitalization in economically underdeveloped and developed regions.