Abstract: The national science and technology awards which include the State Natural Science Award, the State Technological Invention Award, and the State Scientific and Technological Progress Award, are the highest honor granted by the Chinese government to reward great achievement in science and technology. Taking 2661 high-level scientific and technological talents who won the national S&T awards from 2000 to 2019 as the research subjects, this paper analyzes the mobility path of the high-end talent group from birth, education to achievement, and summarizes the mobility pattern of scientific and technological talents in the Beijing-Tianjin-Hebei region, the Yangtze River Delta, and the Guangdong-Hong Kong-Macao Greater Bay Area. Firstly, our results show that the talent flow in the Beijing-Tianjin-Hebei region presents a “single core attraction” pattern. The inbound mobility rates of national S&T awards winners in the Beijing-Tianjin-Hebei region are mostly higher than those in the other two regions. Beijing lured the majority of award winners from both inside and outside the region through its clusters of high-quality universities, research institutes and high-tech enterprises. While the reverse talent flows from Beijing to Tianjin and to Hebei, as well as the talent flow between Tianjin and Hebei are not smooth. Secondly, we find that the talent flow in the Yangtze River Delta appears to be a “self-produced and sold” pattern. The internal flow rates of national S&T awards winners in the Yangtze River Delta are significantly higher than those in the other two regions. The talent flows in Jiangsu, Zhejiang, and Shanghai are all highly localized. Roughly a third of the award winners born in Jiangsu, Zhejiang, and Shanghai finally resettled in the same province, while half of the award winners educated in these three provinces finally stayed to work in the same province. As a result, the talent flow among Jiangsu, Zhejiang and Shanghai is less frequent than the flow inside each province. Talents in Anhui exhibit a different mobility pattern than the rest of the Yangtze River Delta. Anhui has an outbound mobility pattern, and the talent flow between Anhui and the rest of the Yangtze River Delta is week. Lastly, the talent flow in the Greater Bay Area presents an “innovation attraction” pattern. The majority of national S&T awards winners working in the Greater Bay Area were born or educated in other regions. Besides, the Greater Bay Area has the privilege to attract overseas talents. However, the talent flow between Guangdong and Hong Kong faces significant hurdles. Overall, three regions have to overcome similar challenges to achieve talent integration. There are different degrees of localized flow of scientific and technological talents in these three regions, and the talent flows within regions are unbalanced and unobstructed. They have to reduce the adverse effects caused by localized talent flows in most provinces. To realize the integrated development of talents in different regions, we suggest that the Beijing-Tianjin-Hebei region should transform the talent mobility pattern into a “single core spillover” pattern which highlights Beijing’s role of radiation to other parts of the region. The Yangtze River Delta is encouraged to develop an “internal circulation” talent mobility pattern while the Greater Bay Area is recommended to adopt a “combined attraction” talent mobility pattern.