Abstract: In the Yangtze River Delta advanced manufacturing cluster survey data, taking knowledge spillovers as the entry point, using empirical analysis to analyze the relationship between knowledge spillovers and the growth performance of advanced manufacturing cluster companies. 157 Research on the questionnaire data of advanced manufacturing enterprises in the parent triangle area shows that knowledge spillover significantly promotes the growth performance of cluster enterprises; knowledge spillover positively affects enterprise innovation association; among the three dimensions of enterprise innovation association, enterprise cooperation, personnel flow, and enterprise spin-off play an intermediary role.