Abstract: From the perspective of "symbiosis theory", combined with the four core ecological elements of "innovation community - resources - technology - environment", this paper uses the DEMATEL method to rank the importance of 30 measurement indicators, delete the key condition factors, and then use the fsqca method to explore the key path of ries system energy level improvement from the perspective of configuration by mining the antecedent configurations that affect the ries system energy level improvement in the case area. It is found that: (1) innovation subject, innovation resources, innovation environment, collaborative innovation and system opening will have an important impact on the energy level of ries system, which is an important factor determining the energy level of ries system; (2) The four paths that drive the high-energy level are the balanced drive path of "innovative population resource niche environmental niche", "high environmental niche advantageous innovative population" dual drive path, "high resource niche high technology niche" collaborative drive path, "innovative population resource niche technology niche environmental niche" comprehensive coordination path, The above four paths further illustrate that the energy level rise of ries system has "multiple concurrent causality", which promotes the study of ries system from the overall perspective to a certain extent.