Abstract: Industrial technology innovation strategic alliance is a cooperative organization composed of enterprises, universities, research institutes and other organizations with complementary advantages and joint development. Its goal is to enhance the key common technological innovation capability in the industry. The industrial technology innovation strategic alliance is becoming more and more important in the increasingly fierce external competition environment, but it faces various challenges in the process of pursuing the stable development of the alliance. There are many reasons, including opportunism, improper governance mechanism, asymmetric resource dependence and so on. In the aspect of alliance synergy, member conflict and dependence are two important dimensions that affect the stability, and they are also important risk points of alliance collaborative innovation. The key problem is how to manage the possible risks in the process of alliance operation. With the deepening of alliance cooperation, the influences of different factors on alliance stability are intertwined, and multiple and complex factors affect alliance stability through linkage matching. These factors are often interdependent and act together, and the combination of different influencing factors will produce chemical reactions, which will lead to the difference of result. In particular, the matching influence of alliance membership and alliance governance mechanism is difficult to be independent, and the influence of linkage matching on alliance results is often difficult to reflect due to the limitations of traditional linear regression. Based on the integration perspective, and using a cross-sectional questionnaire of 56 pilot industrial technological innovation strategic alliances evaluated by China's Ministry of Science and Technology in 2012, as well as dynamic tracking data of alliance activity from 2013 to 2021, this paper employs the configuration method to investigate the path of alliance handling membership relationships and improving stability. It is found that: Firstly, a single condition does not constitute a necessary condition for high alliance stability, but the coordination mechanism plays a key role when conflicts occur. Secondly, we summarized four paths of alliance membership and governance mechanism to achieve high alliance stability, which helped to provide a comprehensive and unified perspective, and explained why a single contradictory result might be true on the whole. Thirdly, we reveal the hidden asymmetric path between high stability and non-high stability of alliances and its mechanism, and find two configurations that produce non-high alliance stability, that is, the alienation of members and the lack of alliance governance mechanism will both cause alliance instability. This asymmetric path provides new insights for the literature of alliance success and failure. In a word, different from previous cross-sectional studies, we use cross-sectional questionnaire and longitudinal tracking design to break through the time limit, provide new empirical support for alliance research, and have important significance for showing the dynamic evolution of alliance network construction and operation process. On this basis, we summed up three practical inspirations of alliance operation.