Abstract: Establishing ties with scientific partners create an important way for technology-based SMEs to obtain the necessary technological innovation resources for growth. How ties with scientific partners will affect the growth of technology-based SMEs is a question that lacks sufficient attention and needs to be answered. In view of this, according to the resource dependence theory, dynamic capability theory and resource bricolage theory, this paper establishes a chain mediating effect model to explore the impact mechanism of ties with scientific partners on the growth of technology-based SMEs, and further uses 312 survey data of technology-based SMEs for empirical analysis. The research results found that: (1) ties with scientific partners has a significant positive effect on the growth of technology-based SMEs; (2) ties with scientific partners indirectly influences the growth of technology-based SMEs by resource bricolage and technological dynamic capability respectively; (3) resource bricolage and technological dynamic capability play a chain mediating effect between ties with scientific partners and the growth of technology-based SMEs. The research conclusion is beneficial for enhancing the understanding of the relationship between ties with scientific partners on the growth of technology-based SMEs, providing important theoretical basis and practical significance for promoting the growth of technology-based SMEs.