Abstract: The global innovation value chain, as the main way of newly emerging to organize today's international R&D investment transfer, is bound to have a fundamental impact on the micro foundation of global science and technology innovation, it broke the function pattern of Multi-National Corporation overseas investment mainly provide local technical services for its product, is the external performance of the international division of labor further in the depth direction of development. On the basis of the International R&D investment transfer of global innovation value chain model, this paper systematically discusses the motivation, influence, and the enlightenment to the upgrading of China's independent innovation. It holds that the international R&D investment transfer is not the goal，the more important is the implementation way and the significance of driving force and Coordination mechanism behind it to the upgrading of China's independent innovation and regional transformation development.