Abstract: To explore the formation path of how public form the cognitive attitude towards genetically modified food, an empirical analysis was done according to the collected samples from science net and Tianya from the perspective of science literacy. Using the grounded theory, a central path to form cognitive attitude was drawn from the groups with high level of science literacy while the edge path was drawn from the groups with low level science literacy. A complete model was formed with the two paths incorporated. It is concluded that the key to manage the attitude of public in central path is to improve the quality of content. However, the attitude of public in edge path is influenced by content stimulus and opinion leader, which is difficult to regulate directly. By improving the level of science literacy to transform the way that the public form the attitude from edge path to central path, better results of management can be reached.