Abstract: Promoting technology commercialization is an important task to implement the innovation-driven strategy, and the key link of strengthening the close combination of science &technology and economy. As an important force of scientific and technological innovations, how system-transformed research institutes accelerate technology commercialization is a problem to be solved urgently nowadays. Based on this, this paper takes Northwest Institute for Non-ferrous Metal Research which is a model of system-transformed research institutes as an example, deeply explores the internal mechanism of system-transformed research institutes accelerating technology commercialization, analyzes five key elements of accelerating technology commercialization, and puts forward corresponding theoretical propositions. This paper expands the research on research institutes’ technology commercialization, and has distinctive practical guidance significances for system-transformed research institutes’ practice in technology commercialization and science & technology innovation and entrepreneurship.