Abstract: Based on the micro and small enterprise, the paper tries to answer the social responsibility of small and micro enterprises to take positive or negative response to the social responsibility by analyzing the impact mechanism of social responsibility on its open innovation. By the survey of 1095 small and micro enterprises, the paper examines the impact of Micro and Small business social responsibility on the open innovation, and further analysis how depends on the political relationship and environment slack. The results of empirical study show that Micro and Small business social responsibility takes the positive effect on the open innovation, and the effect is moderated by the political relationship and environment slack. Furthermore, the political relationship moderates positively the effect, and the environment slack moderates negatively the effect. The findings provide insights into how micro and small enterprise select social responsibility strategy, and provide new ideas for the firm innovation.