Abstract: Taking 15 typical innovative entrepreneurs in Zhongguancun Science and Technology Park as the target， this study explores the basic qualities and professional capabilities of innovative entrepreneurs through unstructured in-depth interviews and by grounded theory and methods, as well as the relationship and transformation mechanism between the two. The results show that in terms of basic qualities, innovative entrepreneurs have the following characteristics--a personality characteristics coexisting with sensibility and reason, a knowledge foundation that integrates theoretical knowledge and practical experience, and a combination of high intelligence and abundant physical fitness. in the term of developing innovative entrepreneurial activities, they have the ability to identify/create innovative entrepreneurial opportunities and develop innovative opportunities, and the operational capabilities of innovative enterprises. Their professional ability to carry out innovative entrepreneurship is the aggregation, transformation and manifestation of their basic quality around the theme of innovative entrepreneurship, driven by specific opportunities and innovative entrepreneurial consciousness. The generation mechanism model of their professional ability is as follows: Basic quality- (entrepreneurial opportunity + innovation and entrepreneurship awareness)-professional ability transformation. The research conclusions provide theoretical support for the cultivation and evaluation of innovative entrepreneurial talents.