Abstract: Abstract：With the development of digital economy, big data, cloud computing, block chain, artificial intelligence and other digital technology system gradually mature, China's industrial chain gradually towards digitalization, networking and intelligence, digital economy has changed the traditional industrial chain model, effectively improved the industrial chain including various links of R & D, production, transportation and sales. Through big data and cloud computing simulation, digital economy has reduced R & D costs to improve production. Therefore, can the development of digital economy empower the key links of the industry chain, finding out the path of promoting the breakthrough of core "neck" technology to enhance the control ability of key links of the industry chain? Along this line of thought, this paper focuses on two aspects of digital industrialization and industrial digitization, and compares to study the function of digital economy to the control ability of key links in the industrial chain. The digital economy relies on digital technology and uses big data as a key production factor, changing the traditional industrial chain model. This paper combines input-output tables and Guotaian database to statistically measure the data of digital economy, industry chain centrality and intermediation from 2016-2022, and comparatively study the issue of digital industrialization and industry digitization to enhance the control ability of key links of industry chain, and conclude that: First, digital economy, digital industrialization and industry digitization significantly enhance the control ability of key links of industry chain, and the intensity of the role decreases in turn Second, there is regional heterogeneity in the digital economy to enhance the control ability of key links in the industry chain, with the eastern coast to the comprehensive economic zone in the northwest weakening in turn; Third, there is industry heterogeneity in the digital economy to enhance the control ability of key links in the industry chain, with the special equipment to transportation equipment, storage and postal services weakening in turn; Fourth, digital technology innovation takes the mediating effect of the digital economy, digital industrialization, industry digitization and key links in the industry chain. The intensity of intermediary effect of digital economy for industry chain centrality and intermediary degree are 0.4452 and 0.3635 respectively, accounting for 76.36% and 64.45% of the total effect ratio respectively. Accordingly, targeted countermeasure suggestions are proposed. This paper proposes the following countermeasures: First, digital industrialization and industrial digitalization synergistic symbiotic system should be established. China should strengthen the promotion of digital industrialization and industrial digitalization in the same frequency linkage, establish a symbiotic system of synergistic development, effectively drive the key links of the industry chain to improve control capabilities, bridge the digital divide, and share digital achievements. Second, Taking the New National Mechanism advantage to promote the "neck" technology precision breakthrough. China should take advantage of system advantage to promote the digital economy to empower the "neck" industry chain of the core technology, to achieve a safe and stable industry chain, independent and controllable. Third, designing the digital technology innovation targeting target system. China should clearly locate the digital technology innovation target with development strategy, increase the "neck" industry linkage in different industries and regions, promote regional coordinated development, precisely enhance the independent R&D and innovation capability of digital technology, and further enhance the control capability of key links in the industry chain. Accordingly, China should increase support for the digital economy industry, build a production network with a smooth domestic and international cycle to achieve high-quality growth in the whole industrial chain.