Abstract: Aiming at explaining the internal relations between innovation clustering capacity of big state-owned companies and innovation clustering performance, this paper take the research perspective of knowledge integration. Based on multiple innovation clustering case studies of typical big state-owned companies, this paper identified multi-dimensional innovation clustering capacity of these companies, and established influencing process model of innovation clustering capacity to analyzing the mechanism of action. The research results shows that the perfect matching of innovation clustering capacity of big state-owned companies and the process of knowledge integration in the innovation clustering life cycle is the key influence factor to innovation clustering performance, which will enriching the theory of innovation clustering and guiding the cultivation of innovation clustering capacity of big state-owned companies.