Abstract: Based on the literature review, a hypothetical model revolving the relationships among network competence, knowledge management competence and innovation competence is put forward. By taking 162 star-ups in the Pearl River Delta as samples, an empirical study on the model is conducted. The results show that network constructing competence, relationship management competence and role positioning competence all have significantly positive effect on knowledge management competence. Knowledge management competence plays a complete intermediary role in the relationship between and network constructing competence and innovation competence. The relationship management competence and role positioning competence have the direct influence on knowledge management competence, but also has the indirect influence on innovation competence.