Abstract: Industrial Technology Research Institute is a new development institute which gathers many innovators, such as universities, research institutes and enterprises, and integrates scientific research, industry, capital, education and S&T intermediary service. In order to effectively get through the barriers between different types of innovators, and form an effective connection channel between basic researches, applied research and market promotion. In an overall view of cross-organizational knowledge integration, an network-based mode of Industrial Technology Research Institute is designed which can integrate tacit knowledge and code knowledge among academia, technology services sector, industry, finance and government. In the mode, strategic orientations for different types of industrial technology Research Institute are explored, a cross-organizational knowledge integration network of Industrial Technology Research Institute is constructed, relationship among different type of innovators is analyzed, team matrix organization structure is built and operational mechanism is discussed. The proposed mode can provide references for the construction of Chinese Industry Technology Research Institute.