Abstract: Technology commercialization is the main model for the transform of achievements in scientific research of universes. In order to ?ll the funding gap in the progress of technology commercialization and accelerate the commercialization of university innovations in the United States, a new type of organization has emerged—the proof of concept centers(PoCCs). Making full use of regional resources and bring innovation and entrepreneurship together by institutional innovation and open innovation network, PoCCs drive the synergy between universes and industry. From this case, we can conclude some important implications for Chinese universes: universes should construct harmonious innovation ecosystem by organizational innovation and intuitional change, and at the same time engage positively in regional innovation ecosystem.