Abstract: Based on the use of China′s provincial panel data between 2000?2011, taking the driving factors of regional technology transfer as theoretical basis, adopting the method of spatial econometrics,the paper has made an empirical study about the driving mechanism of inter-regional technology transfer. The result shows:The inter-technology transfer often occurs between strong provinces,presents “Mattew effect” such as “the strong get stronger and the weak get weaker”;The inter-regional technology transfer is influenced signifcantly by market demand, basis of regional innovation,funds of regional innovation, behavior of technology transfer of adjacent areas, invironmental factor such as protection of intellectual property rights. The mechanism of inter-regional technology transfer reflects three dominant driving orientations such as market demand,absorptive capacity and competition.The result also implies that technology transfer between adjacent areas presents “horizontal strategic interaction” such as competition or imitation.