Abstract: Abstract: Regional culture embeddedness makes the enterprises in the cluster innovation network become a strong identity, conduce to communicate and learn with each other, lower transaction costs, tend to netting cooperation; But a strong culture embeddedness makes industry cluster lock on the existing development path, lead to a loss of cluster innovation ability. Based on the analysis of related literature and characteristics of cluster innovation network, SIR mathematical model of culture embeddedness is constructed by using the principle of the transmission dynamics, to simulate the spread process of culture embeddedness, conclude that the culture embeddedness in the cluster innovation network is closely related with the average degree of the cluster network, clear the mathematical reasons that the cultural embeddedness lock the cluster innovation on the existing development path from the final state of no spread of SIR mathematical model; and further discussed control strategy for cultural embeddedness phenomenon in the cluster innovation network, to ensure that the cluster benefit from the perspective of cultural philosophy, promote the rapid development of cluster economy.