Abstract: Based on knowledge management theory, this study explores the formation mechanisms/interaction patterns of opposite group cognition with regard to transgenic technology and products by applying case study approach. We find that groups hold different viewpoint due to different knowledge schema: specialized knowledge logic and methodology logic of “for” group; non-specialized knowledge logic and experience logic of “against” group. Knowledge schema will generate corresponding unique information screening strategy and cognitive pattern with distinct focus. Our study not only proposes an integrated cognitive framing, but also discovers that the “for” group has developed two response strategies against “against” group and the interaction pattern shows cognitive bias and potential intersubjective sharing core.