Abstract: As an important area of inter-organizational knowledge management research, collaborative knowledge management practice (CKMP) is considered as the key factor to achieve inter-enterprise knowledge synergy and enhance the ability of cluster innovation. However, Existing studies have failed to thoroughly investigate the relationship between CKMP and organization competitive advantage and how to guide the successful implementation of CKMP. To address this issue, current research identified its antecedents and consequences on the basis of clarifying the content of CKMP. Using surveys from 342industry cluster companies in 5 different regions in China, The empirical research found: (1)CKMP was a multidimensional construct including collaborative knowledge creation, collaborative knowledge storage, accessibility of knowledge acquisition, collaborative knowledge diffusion and collaborative knowledge application; (2)successful implementation of CKMP was influenced by three factors: the characteristics of the organization, The attribute of knowledge, the situation of collaboration; (3)different antecedents have different significant effects on CKMP: the attribute of knowledge had the strongest effect, organizational factors were relatively weaker and situational factors is weakest. (4) CKMP had the positive effect on the knowledge quality, cluster supply chain integration and organizational innovation. This paper established the integration model of CKMP before and consequence variables, which is a powerful supplement to the existing knowledge management theory