Abstract: In the construction of the Silk Road Economic Belt, the railway transport network is an important technic ensurance for the regional economic cooperation. According to the traditional view of technology, the railway, as a technical artifact, can be replicated and diffused in different contexts according to their own logic standard. However, the tortuous destiny of the China-Kyrgyzstan-Uzbekistan railway has indicated that the meaning of the railway had been continuous reshaped by the various local elements, such as economic, cultural, social, especially geopolitics, in the cross-cultural, border, and national process of diffusion. This enlighten us that in the construction of the Silk Road Economic Belt, we should go beyond positivism view of technology, and conscious of local heterogeneous elements in the technology diffusion. Furthermore, with the new thinking of globalization development, we should carry forward the spirit of “peace and cooperation, openness and inclusiveness, mutual learning and mutual benefit”, and keep the principle of “jointly built through consultation to meet the interests of all”, and try to break the geopolitical thinking, reflect and enhance the value pursuit of international relations, in order to advance the connectivity projects to a new level.