Abstract: In order to deal with the adaptive behavior of innovation organization, this paper analysis the emergence characteristics of organizational inertia in technological innovation network. By constructing a framework of structure inertia and cognitive inertia to explore the effect on ambidexterity innovation in different network embeddedness. Then an empirical test is made by multiple regressions with high-tech industry data. The results show that organizational inertia can not only help to promote incremental innovation, but also the structure inertia is better than cognitive inertia for incremental innovation. The relationship between organizational inertia with radical innovation shows a reversed U-shape, the cognitive inertia is better than structure inertia for radical innovation. In the relationships between organizational inertia and ambidexterity innovation, the relational embeddedness’s moderated effect is confirmed. But structure embeddedness’s moderated effect is partly confirmed. This research can reveal the adaptive behavior of innovation organization in technological innovation network, which has significant meaning to improve the innovation ability and stability of technology innovation network.