Abstract: Aiming at the problems and challenges of the Sustainable transformation growth of innovation driven development of high-tech industry in China As well as the characteristics of the non direct correlation between recessive knowledge accumulation and innovation and performance, this paper improve and construct the nonlinear dynamic threshold model of independent R&D innovation driven on science-technology performance from the regional knowledge accumulation perspective and analyze the dynamic threshold effect and the temporal and spatial heterogeneity of regional knowledge accumulation, which is revealed the "black box” in the challenges situation of innovation driven development in method and content. The research shows that: high-tech industry R & D personnel input has a significant promotion to industrial science-technology performance; The technology introduction and transformation are to some extent the negative effect on science-technology performance. The effect of Independent R & D innovation driven on science-technology performance markedly restricted from the level of regional knowledge accumulation of high-tech industry, with knowledge accumulation threshold level upgrade, independent R&D innovation drive efficiency gradually improved, which is existing the double threshold effect of knowledge accumulation, then divided area into three kind of types: low knowledge accumulation (KS≤5.285), medium knowledge accumulation (5.2856.769). At the same time, the level of regional knowledge accumulation in independent R&D innovation driven mechanism existing the temporal and spatial heterogeneity, and the difference of the distribution of different years and regions is larger.