Abstract: Taking the provincial area of the mainland of China as the research object, through the construction of innovation driven evaluation index system, and the use of spatial econometric analysis method, this paper investigates the impact of innovation driven on China's regional economic growth quality. The results show that innovation driven level of western region is higher than the central and western region. The innovation-driven has a significant effect on raising the economic growth quality of the whole country and the East. But its effect on the central region is not obvious. It even has a disadvantage effect on raising the economic growth quality of the western region. The conclusion of this paper is to implement the innovation driven development strategy, and to provide policy implications for the regional healthy development.