Abstract: Government－Industry－University－Research－User （GIURU）Collaborative Innovation is both an effective approach to implement China’s innovation-driven development strategy, and an essential measure to promote industrial competitiveness of the country. Although GIURU Collaborative Innovation has been studied broadly, current research still fails to fully uncover the mechanism of how GIURU Collaborative Innovation improving the enterprises competitiveness. Choosing Nectech Company as the single-case study object, this paper revealed four pivotal factors in the GIURU Collaborative Innovation process. Additionally, from the self-organization theory perspective, this paper constructed a dynamic evolution model of GIURU Collaborative Innovation. These findings have major value in theory and practice to promote GIURU collaborative innovation performance and improve the enterprises competitiveness.