Abstract: This research aims to take Lenovo R&D organization as a case study, to systematically explore evolution path of organization ambidexterity, building competitive advantage for the processes, characteristics and reason. This research find that the key success factor of Lenovo for globalization is its competitive advantages built by its R&D organizational ambidexterity. This paper summarizes the process model of ambidexterity building competitive advantage. In addition, this article analyzed the reason of complex nested organizational ambidexterity promotes the fusion after emerging market corporate mergers and acquisitions developed multinational companies. It also reveals the literal problem of absorptive capacity for Chinese manufacture. The practical significance of this study is to guide Chinese enterprises to achieve organization ambidexterity, to obtain sustainable development competence for innovation and competitive advantage in globalization.