Abstract: The path and focus of the development of Beijing science and technology innovation center have become crack problems to academic circles and politicians. Research on the the development of Beijing science and technology innovation center from the perspective of industrial knowledge bases, Put forward the frame of the two kinds of industrial knowledge bases——synthetic knowledge bases and analytical knowledge bases, impact the the development of Beijing science and technology innovation center. And the entropy method is used to calculate the stock values of the two kinds industry knowledge bases of the provinces (municipalities and autonomous regions)in our country in 2013 and the stock values in the Beijing area from 2000-2013. The two categories of industrial knowledge bases of 2013 in Beijing are made horizontal contrast and vertical contrast. Results display that: contrast to most provinces (municipalities and autonomous regions) in our country, the analytical industrial knowledge base in Beijing is stronger,while the comprehensive knowledge bases is weaker in Beijing. And the two kinds of industrial knowledge bases can‘t meet the needs of the construction of scientific and technological innovation center, in recent years, the growth rate of comprehensive knowledge bases in Beijing is higher than that of analytical knowledge bases. This study provides a basis for the construction of Beijing scientific and technological innovation center.