Abstract: Under the background of the globalization of the world economy, the flow rate of human resources, capital, information, technology is becoming faster and faster in the global scope. It has brought a large number of frontier technology and management experience, also created a good condition for the latecomer firms to capture market opportunities and pursue leading firms. This paper studies the timing choice of disruptive innovation for the latecomer firms, the study found that, dynamic market demand growth rate, consumption preference, market stratification clarity, technical iteration rate, technology innovation space, the difficulty of technology acquisition, industry outlook, industry vertical division, the internal knowledge flow, tax incentives, talent reserves, government services and financing system, a total of 13 factors play an important role in the process of disruptive innovation.