Abstract: The trend of networking of collaborative innovation among industries, universities and research institutes influences knowledge exchange, sharing and integration among such organizations. Therefore, the research on the mechanism of impact of network embeddedness on I-U-R knowledge collaboration is more and more important. Our research, based on the network embeddedness theory, intends to construct a conceptual model in which four factors influence one another like network embeddedness, knowledge search, I-U-R cooperative behavior, and I-U-R knowledge collaboration performance. Supposing knowledge search and I-U-R cooperative behavior as the meditation variables, we testify our research through extensive questionnaires and data analysis and come to the main conclusions as below. Firstly, the network embeddedness reveals a distinctive positive effect on the I-U-P knowledge collaboration performance. Next, the knowledge search and I-U-R cooperative behavior shows a completely meditation effect between the trust and I-U-R knowledge collaboration performance, but a partly meditation effect between the other three factors of network embeddedness and I-U-P knowledge collaboration performance. It is expected that both theoretical and empirical study in this research can broaden the research on network embeddedness and deepen the theoretical scope of I-U-R knowledge collaboration.