Abstract: The cooperative of industry-university-research Institution is one of the main ways for enterprises to gain competitiveness, Enterprises, universities and research institutes are embedded in the network and have an impact on the establishment of network relations and the development of network innovation performance. Based on the social network analysis, relying on QAP method and Ucinet software, the following conclusions can be drawn: The actor’s attribute of the cooperative innovation network is positively related to the cooperative relationship between industry, university and research Institution, and cluster enterprise innovation performance is positively related, too. The small world characteristics of the network are negatively related to the cooperative relationship between industry, university and research Institution, and cluster enterprise innovation performance is negatively related, too. Among them, the roles and positions of university is the most important. Enterprises should further strengthen their cooperation with universities and focus on the establishment and development of research institutions. The development of cluster enterprise innovation performance is due to the cooperative of industry-university-research Institution, but also need to avoid the negative effects of small world characteristics, and strengthen cross-regional and international exchanges