Abstract: From the perspective of technology strategy and innovation economics, this paper analyzes the influence of technological diversification on the persistence of firm’s innovation, and then conducts an empirical test based on a sample of Chinese manufacturing listed firms from the year of 2006 to 2014. The result shows that, technological diversification has a positive influence on firm’s persistent innovation; both related technological diversification and exploitative technological diversification have a positive influence on firm’s persistent innovation, but explorative technological diversification has a negative influence on the persistence of firm’s innovation input. The synergy between related technological diversification and unrelated technological diversification has a positive influence on the persistence of firm’s innovation. However, firm conducts explorative technological diversification and exploitative technological diversification simultaneously will be harmful to its persistent innovation. The paper also finds the different moderating effects of product diversification and complementary assets on the relationship between technological diversification and persistent innovation.