Abstract: In China, during 60 years of development, Large-scale Research Facilities ("LRF" for short) has made brilliant achievements. The current study tries to measure and analyze the evolution situation in time and spatial series of Chinese LRF by using the Information Entropy. The conclusion indicates that the layout of LRF is balanced considering its spatial distribution and its evolution can be further divided into three stages in time series with a pattern of " balance-convergence-balance". From a local point of view, geographic concentration effect becomes more and more obvious, but it presents different patterns in the evolution of the regional development. For those regions with balanced developing LRFs, the developing strategy is to further strengthen the interrelationship between different LRFs to form a discipline complementary and coordinated development atmosphere. For those with LRFs in a state of convergence and unbalance, the diversity of LRFs has to be increased, the advantages of regional resources have to be released and cooperative relations have be promoted. The reasonable layout of LRFs is the premise and foundation for a well utilization and it has to be enhanced. The current paper tries to provide a new analysis method for the research of LRF in order to make the macro policy makers and the micro executive level understand LRF, a highly complex system, objectively and rationally and eventually promote a environmental friendly atmosphere for its development.