Abstract: With the ever-changing of science and technology, globalization continues to deepen development. More and more intense competition among enterprises. So many companies choose M & A or technical strategic alliance or other means to carry out cooperation in order to improve the efficiency of technological innovation and format competitive advantage. The focus of this paper is to study the driving force of technology strategic alliance, cooperation optimization and the factors that affect the stability of the alliance. Through empirical research, mainly from the following aspects to analyze the study to verify the hypothesis and draw conclusions: Firstly, the more intense market competition, the greater the government support and the more obvious demonstration effect of peers, the more dynamic the formation of technology strategic alliance, and thus the more stable strategic alliance; secondly, the Coordination of the leading unit and government norms as different cooperative optimization methods can improve the strategic alliance stability formed under the driving force, and thus promoting optimization. Finally, according to the research results and putting forwards policy recommendations for China’s technology strategic alliance so as to provide reference for the development.