Abstract: How to effectively distinguish the influencing factors of service innovation is an important issue which is faced with the manufacturing enterprises. The paper through literature review identifies distinguishes the influence of four kinds of extension resources on service innovation which are market resources, social resources, technical service resources and intellectual resources. With the aim of distinguishing the influence of these four kinds of extension resources combining with different conditions of the environmental quality and enterprise vitality. The effective data of 303 high-tech manufacturing enterprises are tested by factor analysis, cluster analysis and regression analysis. The results show that four kinds of extension resources have positive effects on service innovation. Intellectual resources contribute most in the combination of four kinds of environmental quality and enterprise vitality, and the technical service resources contribute lest. The effectiveness of four extension resources on service innovation is different under the combination of four enterprise vitality and environmental quality conditions. Under different combinations, manufacturing enterprises should take the suitable case of extension resources according to different stages of developing enterprises. The research deepens the existing research on the factors influencing the service innovation of manufacturing enterprises, and contributes to the sustainable development of enterprises and the maximum utility of service innovation.