Abstract: In this paper, based on the data of Chinese biotechnology firm in 2003-2016 and using fixed-effect Quasi-Poisson model, we investigated the effect of firm’s geographic proximity to other firms in the same industry on its innovative performance, and at the same time, we also consider the structure of the firm’s internal inventor collaboration network and investigated its moderating effect. The results show that geographic proximity promotes firm’s innovation performance; the clustering of intra-firm network positively moderate the relation between geographic proximity and innovative performance; the average path length of the intra-firm network negatively moderate the relation between geographic proximity and innovative performance. The conclusion in this paper provide theoretical guidance to the coordination of firm’s internal knowledge network.