Abstract: The innovation subject of knowledge innovation is universities &research institutions, and the innovation subject of product innovation is enterprises. In order to realize synergy innovation, the key is to promote synergetic development of knowledge and product innovation. Using the method of the grey relational theory and distance collaborative model, this paper measures the synergetic development abilities of knowledge and product innovation of the general, the regional as well as the provincial high-tech enterprises in China from 2006 to 2015. The results show that: (1) the general synergetic development abilities of knowledge and product innovation in high-tech enterprises improving, but its integrated development degree is less than its integrated coordination degree obviously; (2) there are some significant differences in the synergetic development abilities of knowledge and product innovation among the eastern, central, and western regional high-tech enterprises in China: the eastern region is in the lead, the central region is the second, and the western region is the lowest; (3) there are also obvious differences in the synergetic development abilities of knowledge and product innovation among the provincial high-tech enterprises, and disequilibrium. Based on these results, this paper draws some relevant policy implications for promoting the synergetic development of knowledge and product innovation in Chinese high-tech enterprises: The first is strengthening effective combination and matching of knowledge and product innovation in high-tech enterprises, improving the synergetic development speed of its knowledge and product innovation; The second is giving overall consideration, implement different regional policies; The third is concentrating the regional comparative advantage, driving synergetic development.