Abstract: The establishment of the sub-fund of government guide fund for of scientific & technological (S&T) achievements transformation is an important measure to promote the transformation of scientific and technological achievements and realize the drive of scientific and technological innovation.The adoption of a quality management system is a strategic decision for an organization that can help to improve its overall performance and provide a sound basis for sustainable initiatives, including sub-fund of government guide fund. This paper analyzes the need of quality management system in sub-fund of government guide fund for S&T achievement transformation. Moreover, the concept and the quality management model in terms of sub-fund of government guide fund for S&T achievement transformation are presented and redefined. And the general quality model is proposed from the aspect of theory-level. Furthermore, the critical process and advise of implement are proposed.