Abstract: Based on network embeddedness and knowledge management theory, it proposes a conceptual model. Taking cluster enterprises as the object，the conceptual model analyzes the effect of multiple network embeddedness and knowledge creation performance, the mediating effect of knowledge integration and the regulatory role of creation atmosphere．The cluster firms of four industrial clusters in Fujian province are chosen as the research objects in the questionnaire survey, and the structural equation model is used to verify the hypotheses．The result shows that knowledge embeddedness has directly positive effect on knowledge creation performance; knowledge integration plays an intermediary role in the relationship of multiple network embeddedness and knowledge creation performance, but the mechanisms are different. Our empirical findings indicate a full mediating role of internal knowledge integration in structural embeddedness; a full mediating role of external knowledge integration in relational embeddedness; a partially mediating role of both external and internal knowledge integration in knowledge embeddedness; and creation atmosphere plays the moderating role between multiple network embeddedness and knowledge creation performance. The research not only has a theoretical contribution to explain the internal mechanism between multiple network embeddedness and knowledge creation performance with a new perspective，but also gives references for cluster firms to improve knowledge creation performance．