Abstract: Based on the situation of China's research-oriented universities and the obstacles of technology transfer, this paper firstly analyses the connotation of modularity on innovation, discusses the coordinating effects of organizational modularity on technology transfer, and builds the research university's technology transfer related organization model. Moving forward, the technology transfer management practices of MIT, Stanford University and Harvard University are systematically explored in the case study. Finally, the paper also gives some enlightenment to China's research-oriented universities corresponding to technology transfer. Key research finding is obtained that organizational modularity is able to adjust the output and efficiency of technology transfer of research university, which is reflected in some aspects including: (1) the three drivers generated by Government traction, University restraint and Industrial linkage, constitute the collaborative innovation infrastructure to promote the transfer of university technology; (2) the professional and independent technology transfer office in a research university, can play an important role in connecting the supply side and the demand side of scientific and technological innovation. Moreover, the organization system (education & teaching ? technology innovation ? technology transfer) of research universities can also be operated in a benign state combining relevant collaborative mechanisms among organization modules.