Abstract: entrepreneurial persistence is a complex decision, what factors make an entrepreneur stick to build up a firm when others choose to give up? According to the social cognition theory, the behavior of entrepreneurs is affected by both social environment factors and individual factors. This paper collects data through a questionnaire survey to examine the relationship between social support, self-efficacy, entrepreneurial passion and persistence. The results show that social support has a significant positive effect on entrepreneurial persistence. Social self-efficacy plays an intermediary role between social support and entrepreneurial persistence. Entrepreneurial passion plays an intermediary role between social support and entrepreneurial persistence. It is worth noting that entrepreneurial self-efficacy and entrepreneurial passion play a chain intermediary role between social support and entrepreneurial persistence.