Abstract: Hard & core scientific and technological achievements transformation mode is an innovation exploration in systems and mechanisms to form effectively high-quality science and technology supply capacity to support economic development based on market economic conditions and the advantages of China's socialist system. Over the years, aiming to give full play to the fundamental, key and supportive role of scientific and technological innovation in supply-side structural reform and focusing on the major national strategic deployment and the scientific and technological needs of regional economic and social development, the Chinese Academy of Sciences has gradually explored a series of ways to generate high-quality science and technology supply capacity and ways to industrialize cutting-edge science and technology in line with the national strategic positioning of science and technology.